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Importantly, nasal sprays enable rapid absorption through the nasal mucosa, allowing the peptide to bypass first-pass metabolism and enter systemic circulation with greater efficiency

Melatonin also exerts antiestrogenic activity, which is particularly significant in hormone-dependent tumors, regulating the expression and transactivation of the estrogen receptor, and modulating the enzymes involved in the local synthesis of estrogens

Psychiatric symptoms, such as paranoia, anxiety, and psychosis, further correlate with the observed abnormalities in the limbic and orbitofrontal regions (Zweben et al., 2004)

Additionally, DFO, deferiprone and N-acetylcysteine (NAC) have also been classified as ferroptosis inhibitors due to their targeting of other cellular pathways [92]